Pharmacokinetics of oral decongestants.

  title={Pharmacokinetics of oral decongestants.},
  author={Izzy Kanfer and Ros Dowse and V Vuma},
  volume={13 6 Pt 2},
  pages={116S-128S; discussion 143S-146S}
Only three drugs are commonly used as oral decongestants--phenylpropanolamine (PPA), pseudoephedrine (PDE), and phenylephrine (PE). They are all chiral drugs that exist as stereoisomers. It is possible that each enantiomer can reflect significant enantioselective differences with regard to both pharmacokinetic and pharmacodynamic effects. Both PPA and PDE are readily and completely absorbed, whereas PE, with a bioavailability of only approximately 38%, is subject to gut wall metabolism and is… CONTINUE READING