Pharmacokinetics of norfloxacin and its N-desethyl- and oxo-metabolites in broiler chickens.

@article{Anadn1992PharmacokineticsON,
  title={Pharmacokinetics of norfloxacin and its N-desethyl- and oxo-metabolites in broiler chickens.},
  author={Arturo Anad{\'o}n and Mar{\'i}a Rosa Mart{\'i}nez-Larra{\~n}aga and Carlos Velez and Maria Jes{\'u}s Lamas D{\'i}az and Pilar Bringas},
  journal={American journal of veterinary research},
  year={1992},
  volume={53 11},
  pages={2084-9}
}
Norfloxacin was given to 2 groups of chickens (8 chickens/group) at a dosage of 8 mg/kg of body weight, IV and orally. For 24 hours, plasma concentration was monitored serially after each administration. Another group of chickens (n = 30) was given 8 mg of norfloxacin/kg orally every 24 hours for 4 days, and plasma and tissue concentrations of norfloxacin and its major metabolites desethylenenorfloxacin and oxonorfloxacin were determined serially after the last administration of the drug… CONTINUE READING