Pharmacokinetics of norelgestromin and ethinyl estradiol delivered by a contraceptive patch (Ortho Evra/Evra) under conditions of heat, humidity, and exercise.

@article{Abrams2001PharmacokineticsON,
  title={Pharmacokinetics of norelgestromin and ethinyl estradiol delivered by a contraceptive patch (Ortho Evra/Evra) under conditions of heat, humidity, and exercise.},
  author={Larry S. Abrams and Donna M. Skee and Jaya Sudha Natarajan and Frankie A. Wong and Philip T. Leese and George W. Creasy and Mona M. Shangold},
  journal={Journal of clinical pharmacology},
  year={2001},
  volume={41 12},
  pages={
          1301-9
        }
}
The objectives of this randomized, open-label, three-period, incomplete block design study were to evaluate the pharmacokinetics of norelgestromin (NGMN) and ethinyl estradiol (EE) delivered by the contraceptive patch, Ortho Evra/Evra, and to evaluate patch adhesion under conditions of heat, humidity, and exercise. During each treatment period, 30 healthy women wore Ortho Evra on the abdomen for 7 days under one of six conditions (normal activity, sauna, whirlpool, treadmill, cool water… CONTINUE READING
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