Pharmacokinetics of naproxen, its metabolite O‐desmethylnaproxen, and their acyl glucuronides in humans

@article{Vree1993PharmacokineticsON,
  title={Pharmacokinetics of naproxen, its metabolite O‐desmethylnaproxen, and their acyl glucuronides in humans},
  author={T. Vree and M. van den Biggelaar-Martea and C. P. Verwey-van Wissen and J. B. Vree and P. Guelen},
  journal={Biopharmaceutics & Drug Disposition},
  year={1993},
  volume={14}
}
  • T. Vree, M. van den Biggelaar-Martea, +2 authors P. Guelen
  • Published 1993
  • Chemistry, Medicine
  • Biopharmaceutics & Drug Disposition
  • The aim of this investigation was to assess the pharmacokinetics of naproxen in 10 human subjects after an oral dose of 500 mg using a direct HPLC analysis of the acyl glucuronide conjugates of naproxen and its metabolite O‐desmethylnaproxen. The mean t1/2 of naproxen in 9 subjects was 24.7 ± 6.4 h (range 16 to 36 h). The t1/2 of 7.4 as found in subject number 10 must, therefore, be regarded as an extraordinary case (p <0.0153). Naproxen acyl glucuronide accounts for 50.8 ± 7.32 per cent of the… CONTINUE READING
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