Pharmacokinetics of nalidixic acid in man: Hydroxylation and glucuronidation

@article{Vree2005PharmacokineticsON,
  title={Pharmacokinetics of nalidixic acid in man: Hydroxylation and glucuronidation},
  author={T. Vree and W. Wijnands and A. M. Baars and Y. Hekster},
  journal={Pharmaceutisch Weekblad},
  year={2005},
  volume={10},
  pages={193-199}
}
Nalidixic acid is metabolized by hydroxylation to 7-hydroxymethylnalidixic acid∥ and then by oxidation to 7-carboxynalidixic acid.∥ The half-lives of the two elimination phases of nalidixic acid are 0.75 and 2.5 h. The apparent half-lives of the metabolite 7-hydroxymethylnalidixic acid are 2.5 and 5.5 h. Plasma protein binding of nalidixic acid is 95% and that of 7-hydroxymethylnalidixic acid 65%. The renal clearance of nalidixic acid varies between 2 and 25 ml/min and that of 7… Expand
3 Citations
Direct gradient reversed-phase HPLC analysis and preliminary pharmacokinetics of nalidixic acid, 7-hydroxymethylnalidixic acid, 7-carboxynalidixic acid, and their corresponding glucuronide conjugates in humans
A gradient reversed-phase high pressure liquid chromatographic analysis was developed for the direct measurement of nalidixic acid with its acyl glucuronide, 7-hydroxymethylnalidixic acid with itsExpand
Enhancement of nalidixic acid solubility via cosolvency and solid dispersion
Nalidixic acid is practically insoluble in water therefore the aim of this study was to study the effect of both cosolvency and solid dispersion on its solubility. Among different cosolvents, theExpand
Formulation and clinical evaluation of some new nalidixic acid topical formulations
In a novel attempt, nalidixic acid was formulated in different topical 1 % (w/w) gel and cream bases. The viscosity, pH and drug content of preparations were investigated. The highest in vitroExpand

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