Pharmacokinetics of molsidomine and of its active metabolite, SIN-1 (or linsidomine), in the elderly.

@article{SpreuxVaroquaux1991PharmacokineticsOM,
  title={Pharmacokinetics of molsidomine and of its active metabolite, SIN-1 (or linsidomine), in the elderly.},
  author={Odile Spreux-Varoquaux and Bastian Ulmer and Prof. D. J. Cordonnier and A Forestier and M. Pays and C Ducreuzet and Charles Advenier},
  journal={Fundamental & clinical pharmacology},
  year={1991},
  volume={5 6},
  pages={549-56}
}
The pharmacokinetics of molsidomine were investigated in six young (25.5 +/- 0.6 years) and in six elderly healthy volunteers (81.1 +/- 3.1 years). After a 2 mg oral administration, molsidomine elimination half-life was prolonged in elderly subjects (1.9 +/- 0.2 h versus 1.2 +/- 0.1 h, P less than 0.05) because of a decrease in its plasma clearance (15.1… CONTINUE READING