Pharmacokinetics of methotrexate in rabbit skin and plasma after iv-bolus and iontophoretic administrations.

Abstract

The pharmacokinetics of methotrexate (MTX) in rabbit's skin and plasma after iv-bolus and iontophoretic delivery at different current densities was studied. Linear microdialysis probes were introduced into the upper dorsal shaved skin of tranquilized rabbits. Commercially available patches were used to deliver MTX for 1 h at different current densities (100… (More)

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