Pharmacokinetics of methotrexate-albumin conjugates in tumor-bearing rats.

@article{Stehle1997PharmacokineticsOM,
  title={Pharmacokinetics of methotrexate-albumin conjugates in tumor-bearing rats.},
  author={Gerd Stehle and Andreas Wunder and Hannsj{\"o}rg Sinn and H H Schrenk and S. Sch{\"u}tt and Emil Frei and Gernot Hartung and W Maier-borst and Dieter L. Heene},
  journal={Anti-cancer drugs},
  year={1997},
  volume={8 9},
  pages={
          835-44
        }
}
  • Gerd Stehle, Andreas Wunder, +6 authors Dieter L. Heene
  • Published in Anti-cancer drugs 1997
  • Medicine
  • Linking chemotherapeutic drugs to a macromolecular carrier system may enhance tumor targeting, reduce toxicity and overcome drug resistance mechanisms. As an elementary model to evaluate the pharmacological properties of macromolecular drug carrier systems we chose rat serum albumin (RSA) for carrier and methotrexate (MTX) as antineoplastic drug. The conjugation procedure yielded conjugates with an approximate 1:1 molar loading rate (MTX(1)-RSA). In the first part of the study a residualizing… CONTINUE READING

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