Pharmacokinetics of metformin after intravenous and oral administration to man

@article{Pentikinen2004PharmacokineticsOM,
  title={Pharmacokinetics of metformin after intravenous and oral administration to man},
  author={Pertti J. Pentik{\"a}inen and Pertti J. Neuvonen and Aneri Penttil{\"a}},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={16},
  pages={195-202}
}
SummaryThe kinetics of14C-metformin have been studied in five healthy subjects after oral and intravenous administration. The intravenous dose was distributed to a small central compartment of 9.9±1.61 ( $$\bar X$$ ±SE), from which its elimination could be described using three-compartment open model. The elimination half-life from plasma was 1.7±0.1 h. Urinary excretion data revealed a quantitatively minor terminal elimination phase with a half-life of 8.9±0.7 h. After the intravenous dose… 
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