Pharmacokinetics of levetiracetam after oral and intravenous administration of a single dose to clinically normal cats.

@article{Carnes2011PharmacokineticsOL,
  title={Pharmacokinetics of levetiracetam after oral and intravenous administration of a single dose to clinically normal cats.},
  author={Michelle Brogan Carnes and Todd W. Axlund and Dawn Merton Boothe},
  journal={American journal of veterinary research},
  year={2011},
  volume={72 9},
  pages={1247-52}
}
OBJECTIVE To determine whether therapeutic concentrations of levetiracetam can be achieved in cats and to establish reasonable i.v. and oral dosing intervals that would not be associated with adverse effects in cats. ANIMALS 10 healthy purpose-bred cats. PROCEDURES In a randomized crossover study, levetiracetam (20 mg/kg) was administered orally and i.v. to each cat. Blood samples were collected 0, 10, 20, and 40 minutes and 1, 1.5, 2, 3, 4, 6, 9, 12, and 24 hours after administration… CONTINUE READING

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