Pharmacokinetics of lacosamide and omeprazole coadministration in healthy volunteers: results from a phase I, randomized, crossover trial.

Abstract

BACKGROUND The antiepileptic drug lacosamide has a low potential for drug-drug interactions, but is a substrate and moderate inhibitor of the cytochrome P450 (CYP) enzyme CYP2C19. OBJECTIVE This phase I, randomized, open-label, two-way crossover trial evaluated the pharmacokinetic effects of lacosamide and omeprazole coadministration. METHODS Healthy… (More)
DOI: 10.1007/s40261-014-0177-2

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@article{Cawello2014PharmacokineticsOL, title={Pharmacokinetics of lacosamide and omeprazole coadministration in healthy volunteers: results from a phase I, randomized, crossover trial.}, author={Willi Cawello and Christa Mueller-Voessing and Andreas Fichtner}, journal={Clinical drug investigation}, year={2014}, volume={34 5}, pages={317-25} }