Pharmacokinetics of ketotiffn after oral administration to healthy male subjects

  title={Pharmacokinetics of ketotiffn after oral administration to healthy male subjects},
  author={Anders Grahn{\'e}n and Anna L{\"o}nnebo and Olof Beck and S-{\AA}. Eckern{\"a}s and Bengt E. Dahlstr{\"o}m and Bj{\"o}rn Lindstr{\"o}m},
  journal={Biopharmaceutics \& Drug Disposition},
The pharmacokinetics of 2 mg ketotifen from four different oral dosage forms were examined in two randomized, balanced cross‐over studies. Forty healthy male subjects participated. Each of 20 subjects received two capsule formulations and each of the other 20 subjects received two syrup formulations. Ketotifen concentrations in plasma were determined by a modified GC—MS method. The limit of quantitation was 40 pg ml−1. Inter‐day precision and accuracy calculated from quality control samples… 
Pharmacokinetics of ketotifen fumarate after intravenous, intranasal, oral and rectal administration in rabbits.
The results indicated that the intranasal route appears the most effective for administering KF, and that rectal administration may be superior to oral administration in terms of bioavailability.
Bioequivalence assessment of Fumatifen® tablet to Zaditen® tablet (ketotifen fumarate 1 mg) by liquid chromatography tandem mass spectrometry
A sensitive and specific liquid chromatographic method coupled with tandem mass spectrometry was developed and validated for the analysis of ketotifen. After treated by liquid–liquid extraction,
In vitro-in vivo correlation of a modified-release oral form of ketotifen: in vitro dissolution rate specification.
A reliable prediction of the plasma concentrations obtained following a single dose or at steady state was found and the reliability of this prediction was validated from variants of MR tablet presenting different in vitro dissolution rate profiles and with an upscaled batch which was tested in vivo.
Determination of ketotifen in human plasma by LC-MS.
Determination of ketotifen and its conjugated metabolite in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study.
A sensitive and specific liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed for the investigation of the pharmacokinetics of ketotifen and its major metabolite, kettifen N-glucuronide, in human plasma, which offered increased sensitivity, selectivity and speed of analysis, compared with existing methods.
Conjugation of the enantiomers of ketotifen to four isomeric quaternary ammonium glucuronides in humans in vivo and in liver microsomes.
Differential hydrolysis or membrane transport may be responsible for the discrepancy between N-glucuronide isomer ratios in vitro and in vivo.
Determination of Ketotifen Fumarate in Syrup Dosage Form by High Performance Liquid Chromatography
The goal of the current study was to establish and authenticate an isocratic reverse-stage High-Performance Liquid Chromatography (HPLC) method for quantifying ketotifen fumarate (KF) in
Development and Validation of a Rapid HPLC Method for the Determination of Ketotifen in Pharmaceuticals
  • M. Elsayed
  • Chemistry, Medicine
    Drug development and industrial pharmacy
  • 2006
A simple, sensitive, rapid, and stability-indicating high performance liquid chromatographic (HPLC) method with ultraviolet detection for the analysis of ketotifen was developed and validated and can be used for routine quality control analysis.
Spectrophotometric Determination of Ketotifen Fumarate in Pure and Pharmaceutical Preperations by Bromophenol Blue Reagent
A spectrophotometric reliable, rapid and sensitive method has been developed and validated for  the determination Ketotifen fumarate  . A method was described for the determination of Ketotifen


Quantification of ketotifen and its metabolites in human plasma by gas chromatography mass spectrometry.
Gas chromatography mass spectrometry with selected ion monitoring has been used and the methodology has been applied in studies of the kinetics of the drug in man, and plasma levels of the unchanged drugs and its metabolites in free and conjugated form are reported.
A controlled trial of ketotifen in exercise-induced asthma.