Pharmacokinetics of ketoconazole administered intravenously to dogs and orally as tablet and solution to humans and dogs.

@article{Baxter1986PharmacokineticsOK,
  title={Pharmacokinetics of ketoconazole administered intravenously to dogs and orally as tablet and solution to humans and dogs.},
  author={J. G. Baxter and C T Brass and Jerome J. Schentag and Richard L Slaughter},
  journal={Journal of pharmaceutical sciences},
  year={1986},
  volume={75 5},
  pages={443-7}
}
The single-dose pharmacokinetics and bioavailability of three ketoconazole formulations were evaluated using HPLC in five healthy human volunteers and six male mongrel dogs. The human volunteers received 400 mg po of ketoconazole as tablet (Ktab) and solution (Ksol) formulations. The dogs received 400 mg po of Ktab and Ksol, and 376 mg iv of an intravenous dose (Kiv). In humans the AUC value for Ksol (62.21 +/- 21.2 microgram X h/ml; mean +/- SD) was significantly greater than for Ktab (50.0… CONTINUE READING

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