Pharmacokinetics of ketamine in man.

  title={Pharmacokinetics of ketamine in man.},
  author={J Wieber and Roland Gugler and J. H. Hengstmann and Hans J. Dengler},
  journal={Der Anaesthesist},
  volume={24 6},
A method for the analysis of ketamine and of its metabolites is described using gas-liquid chromatography for separation and flame ionization detection. The lower limit of detection for ketamine in serum was 0.025 mug/ml. The pharmacokinetic behaviour of ketamine after intravenous injection may be described in terms of an open two-compartment model. The… CONTINUE READING