Pharmacokinetics of itraconazole following oral administration to normal volunteers.

@article{Hardin1988PharmacokineticsOI,
  title={Pharmacokinetics of itraconazole following oral administration to normal volunteers.},
  author={Thomas C. Hardin and John Richard Graybill and R J Fetchick and R. J. H. Woestenborghs and Michael G. Rinaldi and John G. Kuhn},
  journal={Antimicrobial agents and chemotherapy},
  year={1988},
  volume={32 9},
  pages={1310-3}
}
The pharmacokinetics of itraconazole, an orally effective, broad-spectrum, systemic antifungal agent, were evaluated in five healthy male volunteers. Each subject was studied on days 1 and 15 at the following dosages: 100 mg once daily (regimen A), 200 mg once daily (regimen B), and 200 mg twice daily (regimen C). On each study day, itraconazole was administered with a standardized meal. Plasma samples were collected for 72 h postdose, and 24-h urine specimens were obtained. On day 1 of regimen… CONTINUE READING

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J. Heykants, M. Michiels, +6 authors G. Cauwenbergh
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