Pharmacokinetics of isoniazid with or without ofloxacin

  title={Pharmacokinetics of isoniazid with or without ofloxacin},
  author={Sinyeofori A. Brown and Ndidiamaka A. Ezejiofor and Orish Ebere Orisakwe},
Objective of the resent study was to determine the effect of ofloxacin (OXC) on the pharmacokinetics of isoniazid (INH). Five healthy volunteers aged 18 – 39 years participated in this study after an informed consent. The study was carried out in two phases with an interval of one-week drug wash out period in between phases. In phase one (INH alone), each subject received 300mg of isoniazid (INH) with 350ml of water after an overnight fast. The subjects were made to fast 2 hours post drug. In… CONTINUE READING