Corpus ID: 33296363

Pharmacokinetics of inulin in blood and central lymph in the rat.

  title={Pharmacokinetics of inulin in blood and central lymph in the rat.},
  author={J. Lamka},
  journal={Polish journal of pharmacology and pharmacy},
  volume={44 2},
  • J. Lamka
  • Published 1992
  • Chemistry, Medicine
  • Polish journal of pharmacology and pharmacy
  • Inulin was used as a model drug for the study of factors influencing the transport of drugs across the blood-lymph barrier. The model drug was administered iv (0.75, 7.5 and 37.5 mg/kg) as a bolus and by infusion. Kinetic parameters in blood and central lymph including lymphatic bioavailability (FL) were determined. It has been found that FL is influenced (increased) by larger doses of inulin (FL extent 0.934 +/- 0.250 - 1.914 +/- 0.250), infusion concentration ratio lymph/blood in steady state… CONTINUE READING
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