Pharmacokinetics of intravitreal ranibizumab (Lucentis).

@article{Bakri2007PharmacokineticsOI,
  title={Pharmacokinetics of intravitreal ranibizumab (Lucentis).},
  author={Sophie J. Bakri and Melissa R. Snyder and J. Macnair Reid and Jos{\'e} S. Pulido and Mohamed Ezzat and Ravinder Jit Singh},
  journal={Ophthalmology},
  year={2007},
  volume={114 12},
  pages={
          2179-82
        }
}
PURPOSE To describe the pharmacokinetics of 0.5 mg of intravitreal ranibizumab (Lucentis) and to compare it with that of 1.25 mg of intravitreal bevacizumab (Avastin), using the same rabbit model. DESIGN Experimental animal study. PARTICIPANTS Twenty-eight Dutch-belted rabbits. METHODS One eye of each of 20 rabbits was injected with 0.5 mg of intravitreal ranibizumab. Both eyes of each of 4 rabbits were enucleated at days 1, 3, 8, 15, and 29. Ranibizumab concentrations were measured in… CONTINUE READING
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