Pharmacokinetics of intravenously administered stealth liposomal doxorubicin modulated with verapamil in rats.

@article{Wang2006PharmacokineticsOI,
  title={Pharmacokinetics of intravenously administered stealth liposomal doxorubicin modulated with verapamil in rats.},
  author={Jian-cheng Wang and Xiaoyan Liu and Wan-liang Lu and Alex Chang and Qiang Zhang and Boon-cher Goh and How-sung Lee},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2006},
  volume={62 1},
  pages={44-51}
}
Treatment of cancer through co-administration of anticancer drugs and multidrug resistance (MDR) modulators as a strategy to overcome drug resistance has been extensively explored. However, success has been limited by pharmacokinetic interactions because of non-specific blockade of P-glycoprotein (P-gp) in normal tissues or inability to reach relevant concentrations clinically. We hypothesized that stealth liposomal co-encapsulation of doxorubicin (DOX) with a P-glycoprotein inhibitor… CONTINUE READING

From This Paper

Topics from this paper.
12 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…