Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination.

@article{Ko1989PharmacokineticsOI,
  title={Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination.},
  author={Hong Kong Ko and Kathleen N. S. Cathcart and D L Griffith and Gary R. Peters and W. J. Adams},
  journal={Antimicrobial agents and chemotherapy},
  year={1989},
  volume={33 3},
  pages={356-61}
}
Sixteen healthy male volunteers participated in a randomized, balanced, three-way crossover study comparing the pharmacokinetics of cefmetazole, cefoxitin, and cefmetazole with probenecid pretreatment. Single 2-g doses of cefmetazole sodium and cefoxitin sodium were given intravenously as a 5-min infusion. Concentrations of cefmetazole and cefoxitin were determined by using a specific semiautomated high-performance liquid chromatographic method. Concentration-time profiles of cefmetazole and… CONTINUE READING

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