Pharmacokinetics of intravenously, intramuscularly and intra-adiposely administered carazolol in pigs.

@article{Kadir1990PharmacokineticsOI,
  title={Pharmacokinetics of intravenously, intramuscularly and intra-adiposely administered carazolol in pigs.},
  author={Fahmi Kadir and Jan Zuidema and Anton Pijpers and Roxana Melendez and Arnold Vulto and Jos H. M. Verheijden},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={1990},
  volume={13 4},
  pages={
          350-5
        }
}
The beta-blocking agent carazolol is used for the prevention of stress syndromes in pigs. Little is known of the pharmacokinetics of this drug, and therefore of its residue status in meat. In this study carazolol pharmacokinetics were investigated in a randomized three-way cross-over design in five pigs. A dose of 0.025 mg/kg was given intravenously, intramuscularly and intra-adiposely (in the subcutaneous fat layer). Carazolol was rapidly distributed and had a short half-life of 1.2-4.2 h. The… CONTINUE READING
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