Pharmacokinetics of intravenous sildenafil in children with palliated single ventricle heart defects: effect of elevated hepatic pressures.

@article{Hill2016PharmacokineticsOI,
  title={Pharmacokinetics of intravenous sildenafil in children with palliated single ventricle heart defects: effect of elevated hepatic pressures.},
  author={Kevin D. Hill and Mario R Sampson and Jennifer S. Li and Robert D Tunks and Scott R. Schulman and Michael Cohen-Wolkowiez},
  journal={Cardiology in the young},
  year={2016},
  volume={26 2},
  pages={354-62}
}
UNLABELLED Aims Sildenafil is frequently prescribed to children with single ventricle heart defects. These children have unique hepatic physiology with elevated hepatic pressures, which may alter drug pharmacokinetics. We sought to determine the impact of hepatic pressure on sildenafil pharmacokinetics in children with single ventricle heart defects. METHODS A population pharmacokinetic model was developed using data from 20 single ventricle children receiving single-dose intravenous… CONTINUE READING