Pharmacokinetics of intravenous procaine infusion in humans.

  title={Pharmacokinetics of intravenous procaine infusion in humans.},
  author={Astrid Seifen and Aurora Ferrari and Ernst Seifen and Dola S. Thompson and Jnani Chapman},
  journal={Anesthesia and analgesia},
  volume={58 5},
Pharmacokinetic data during and following the continuous intravenous infusion of procaine are lacking. We studied 12 women undergoing hysterectomy during N2O-O2 and narcotic anesthesia. A constant infusion of 2% procaine was administered at a rate of 1 mg/kg/min to six patients (group I) and at a rate of 1.5 mg/kg/min to the other six (group II). Procaine plasma levels were determined by flame ionization gas-liquid chromatography. Using a two-compartment pharmacokinetic model, disposition… CONTINUE READING
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