Pharmacokinetics of intravenous fluticasone propionate in healthy subjects.

  title={Pharmacokinetics of intravenous fluticasone propionate in healthy subjects.},
  author={Alan Mackie and G. P. Ventresca and Richard W Fuller and A. R. Bye},
  journal={British journal of clinical pharmacology},
  volume={41 6},
1. Fluticasone propionate (FP) is a potent glucocorticoid used in the treatment of asthma. Prior to reporting the pharmacokinetics following the inhaled and oral routes, the pharmacokinetics need to be established following intravenous dosing. The present study determines the intravenous pharmacokinetics of FP, using non-compartmental analysis, in healthy male subjects over the 250 to 1000 micrograms dose range. 2. The pharmacokinetics of FP can be regarded as being linear over this dosing… CONTINUE READING
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