Pharmacokinetics of intravenous and oral midazolam in plasma and saliva in humans: usefulness of saliva as matrix for CYP3A phenotyping.

Abstract

AIMS To compare midazolam kinetics between plasma and saliva and to find out whether saliva is suitable for CYP3A phenotyping. METHODS This was a two way cross-over study in eight subjects treated with 2 mg midazolam IV or 7.5 mg orally under basal conditions and after CYP3A induction with rifampicin. RESULTS Under basal conditions and IV administration… (More)
DOI: 10.1111/j.1365-2125.2008.03201.x

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@article{Link2008PharmacokineticsOI, title={Pharmacokinetics of intravenous and oral midazolam in plasma and saliva in humans: usefulness of saliva as matrix for CYP3A phenotyping.}, author={Bettina Link and Manuel Haschke and Nathalie Grignaschi and M. D. V. Bodmer and Yvonne Zysset Aschmann and Markus Wenk and Stephan Kr{\"a}henb{\"u}hl}, journal={British journal of clinical pharmacology}, year={2008}, volume={66 4}, pages={473-84} }