Pharmacokinetics of intravenous and oral dihydrocodeine and its acid metabolites

  title={Pharmacokinetics of intravenous and oral dihydrocodeine and its acid metabolites},
  author={F. Rowell and R. Seymour and M. Rawlins},
  journal={European Journal of Clinical Pharmacology},
SummarySerum concentrations of dihydrocodeine and its acid metabolites have been determined in seven human volunteers (6 male) who received the drug orally (30 mg and 60 mg) and intravenously (30 mg) on separate occasions, and in twenty-four patients (12 male) receiving 25 mg or 50 mg of the drug intravenously. The concentrations were estimated by radioimmunoassay on reconstituted extracts from serum after an extraction process which effectively separates dihydrocodeine from its polar acidic… Expand
Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling
The developed model simulated the pharmacokinetic profiles of dihydrocodeine after single and multiple oral administrations reasonably well in the same population and suggested that the dihydrcodeine PBPK model reproduced the results of clinical cases reasonably well for subjects. Expand
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A simple and sensitive liquid chromatography method for the determination of low dihydrocodeine concentrations in human plasma: its application in Chinese healthy volunteers.
The validated method, developed for determination of low dihydrocodeine concentrations in human plasma by high performance-liquid chromatography (HPLC) with diode array detector, was successfully applied to a bioequivalence study of dihydROcodeine after a single oral administration of 20 mg dihydrosodium tartrate in Chinese healthy male volunteers. Expand
Hemodynamic effects of methadone and dihydrocodeine in overdose
It is suggested that dihydrocodeine and methadone in overdose both have a significant effect on central and peripheral hemodynamics, providing a pharmacological explanation for the apparent benefit of opioids in cardiovascular diseases. Expand
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Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults.
There is insufficient evidence to support or refute the suggestion that paracetamol alone, or in combination with codeine or dihydrocodeine, works in any neuropathic pain condition. Expand
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1 The elimination and metabolism of diazepam in man was investigated following the induction of the liver microsomal enzyme system by antipyrine. 2 Seven healthy volunteers were given 1200 mgExpand
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