Pharmacokinetics of intravenous and oral dihydrocodeine and its acid metabolites

@article{Rowell2004PharmacokineticsOI,
  title={Pharmacokinetics of intravenous and oral dihydrocodeine and its acid metabolites},
  author={F. Rowell and R. Seymour and M. Rawlins},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={25},
  pages={419-424}
}
SummarySerum concentrations of dihydrocodeine and its acid metabolites have been determined in seven human volunteers (6 male) who received the drug orally (30 mg and 60 mg) and intravenously (30 mg) on separate occasions, and in twenty-four patients (12 male) receiving 25 mg or 50 mg of the drug intravenously. The concentrations were estimated by radioimmunoassay on reconstituted extracts from serum after an extraction process which effectively separates dihydrocodeine from its polar acidic… Expand
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