Pharmacokinetics of intravenous and oral prednisolone.

  title={Pharmacokinetics of intravenous and oral prednisolone.},
  author={Sayed M. H. Al-Habet and Howard J. Rogers},
  journal={British journal of clinical pharmacology},
  volume={10 5},
1 Doses of 16, 32, 48 and 64 mg prednisolone were administered intravenously to normal volunteers who also received 100 prednisolone orally. Plasma prednisolone concentrations were estimated by quantitative thin layer chromatography. 2 The bioavailability fraction was 1.063 +/- 0.154 (s.d.) indicating complete availability of prednisolone following oral administration. 3 The mean T 1/2 over all doses were 4.11 +/- 0.97 (s.d.) h and there was no evidence of a dose-related change in its value. 4… CONTINUE READING

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