Pharmacokinetics of intravenous isosorbide-dinitrate

@article{Platzer1982PharmacokineticsOI,
  title={Pharmacokinetics of intravenous isosorbide-dinitrate},
  author={Rudolf Platzer and Georg Reutemann and R. Galeazzi},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1982},
  volume={10},
  pages={575-586}
}
The kinetics of isosorbide dinitrate (ISDN) after i.v. administration and the absolute availability of an oral slow release preparation (SR) were studied in young healthy volunteers. ISDN and the 2- and 5-mononitrates of isosorbide (2-MN, 5-MN) were determined by GLC. After i.v. administration plasma levels of ISDN declined biexponentially and could be adequately described by an open two compartment body model. Distribution half-life was extremely rapid (2–5 min). Terminal disappearance had a… CONTINUE READING

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