Pharmacokinetics of intravenous N-acetylcysteine in pre-term new-born infants

@article{Ahola1999PharmacokineticsOI,
  title={Pharmacokinetics of intravenous N-acetylcysteine in pre-term new-born infants},
  author={Tapani Ahola and Vineta Fellman and Reijo Laaksonen and Jouko Laitila and Risto Lapatto and Pertti J Neuvonen and Kari O. Raivio},
  journal={European Journal of Clinical Pharmacology},
  year={1999},
  volume={55},
  pages={645-650}
}
Background: Reactive oxygen species have been considered to play a role in several clinical complications in pre-term infants. The aim of this study was to determine the pharmacokinetics of intravenous N-acetylcysteine in pre-term neonates. This information is needed to evaluate the use of N-acetylcysteine as an antioxidant in this patient group. Methods: N-acetylcysteine was infused intravenously in ten patients (gestational age 24.9–31.0 weeks, weight 500–1384 g) for 24 h (3.4–4.6 mg/kg/h… CONTINUE READING

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