Pharmacokinetics of inhaled colistimethate sodium (CMS) in mechanically ventilated critically ill patients

  title={Pharmacokinetics of inhaled colistimethate sodium (CMS) in mechanically ventilated critically ill patients},
  author={Zoe E. Athanassa and Sophia L. Markantonis and Marina-Zoe F. Fousteri and Pavlos Myrianthefs and Eleni G. Boutzouka and Athanassios Tsakris and George J. Baltopoulos},
  journal={Intensive Care Medicine},
The purpose of this study was to describe inhaled colistin pharmacokinetics in patients with ventilator-associated tracheobronchitis (VAT) due to polymyxin-only susceptible Gram-negative bacteria (GNB). Inhaled colistimethate sodium (CMS) was administered at a dose of 80 mg every 8 h for 7 days. Mini bronchoalveolar lavage (BAL) was performed before and at 1, 4 and 8 h, while blood samples were collected before and at 0.16, 0.5, 1, 2, 4 and 8 h after the first dose. Colistin concentrations in… CONTINUE READING


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