Pharmacokinetics of ifosfamide and some metabolites in children.

Abstract

The pharmacokinetics of ifosfamide and some metabolites in children was investigated. The patients received various doses of ifosfamide, mostly by continuous infusion, over several days. The penetration of ifosfamide and its metabolites into the cerebrospinal fluid was also studied in four cases. Ifosfamide and 4-hydroxyifosfamide pass the blood-brain barrier, reaching cerebrospinal fluid concentrations that are almost as high as plasma concentrations.

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@article{Kaijser1998PharmacokineticsOI, title={Pharmacokinetics of ifosfamide and some metabolites in children.}, author={Gerry Kaijser and Jan de Kraker and Auke Bult and Willy J. M. Underberg and J H M Beijnen}, journal={Anticancer research}, year={1998}, volume={18 3B}, pages={1941-9} }