Pharmacokinetics of ibutilide and its enantiomers in dogs.


Ibutilide fumarate, a new drug for the treatment of cardiac arrhythmias, contains a stereogenic center bearing a secondary alcohol group. Several single dose and multiple dose studies of racemic ibutilide or its enantiomers were performed by the oral and intravenous routes in dogs. A chiral assay was used to examine racemization and the individual… (More)


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@article{Hsu1996PharmacokineticsOI, title={Pharmacokinetics of ibutilide and its enantiomers in dogs.}, author={C. Y. Hsu and Ron Walters}, journal={Chirality}, year={1996}, volume={8 1}, pages={18-23} }