Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax.

@article{Lim2009PharmacokineticsOH,
  title={Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax.},
  author={Hyeong-Seok Lim and Jeong-Soo Im and Joo-Youn Cho and Kyun-Seop Bae and Terry A. Klein and Joon-Sup Yeom and Tae-Seon Kim and Jae-Seon Choi and I. C. Jang and Jae-Won Park},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 4},
  pages={1468-75}
}
Hydroxychloroquine (HCQ) is an antimalarial drug used as chemoprophylaxis against malaria caused by Plasmodium vivax in the Republic of Korea Army (ROKA). In this study, we evaluated the pharmacokinetics (PK) of HCQ and its metabolites and the relationship between the PK of HCQ and the effect of treatment of HCQ on vivax malaria in South Koreans. Three PK studies of HCQ were conducted with 91 healthy subjects and patients with vivax malaria. Plasma concentrations were analyzed by… CONTINUE READING