Pharmacokinetics of hydralazine, apparent hydralazine and hydralazine pyruvic acid hydrazone in humans.

@article{Shepherd1979PharmacokineticsOH,
  title={Pharmacokinetics of hydralazine, apparent hydralazine and hydralazine pyruvic acid hydrazone in humans.},
  author={Alexander M. M. Shepherd and Thomas M. Ludden and K. Haegele and T. Talseth and J. L. Mcnay},
  journal={Research communications in chemical pathology and pharmacology},
  year={1979},
  volume={26 1},
  pages={129-44}
}
Hydralazine is an antihypertensive vasodilator agent. Lack of specific assay techniques for its measurement have delayed elucidation of its pharmacokinetic profile. This study compares the plasma profiles of hydralazine, measured both by a specific and by a previously published nonspecific assay and of a major plasma metabolite, hydralazine pyruvic acid hydrazone. After po and iv administration of hydralazine, peak hydralazine levels were lower (7-33%) and plasma half lives were shorter (15-31… CONTINUE READING