Pharmacokinetics of human leptin in mice and rhesus monkeys

  title={Pharmacokinetics of human leptin in mice and rhesus monkeys},
  author={Bo Ahr{\'e}n and R D Baldwin and P J Havel},
  journal={International Journal of Obesity},
OBJECTIVE: The pharmacokinetic characteristics of human leptin were examined in rhesus monkeys and in C57BL/6J mice fed a normal chow or a high-fat diet.DESIGN: For the monkey study, in nine rhesus monkeys (body weight 12.4±2.4 kg; mean±s.d.), recombinant met-human leptin was injected intravenously or subcutaneously (1 mg/kg). For the mouse study, after 6 months of feeding C57BL/6J mice a high-fat diet (body weight 32.9±3.6 g; n=8) or a control diet (24.5±1.2 g; n=6), recombinant met-human… CONTINUE READING


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