Pharmacokinetics of high-dose thiopental in pediatric patients with increased intracranial pressure.

@article{Russo1997PharmacokineticsOH,
  title={Pharmacokinetics of high-dose thiopental in pediatric patients with increased intracranial pressure.},
  author={H{\'e}l{\`e}ne Russo and Françoise Bressolle and M. P. Duboin},
  journal={Therapeutic drug monitoring},
  year={1997},
  volume={19 1},
  pages={63-70}
}
This study was conducted on 10 pediatric patients in whom intracranial hypertension stemming from head injury was reduced by high-dose thiopental administered for a prolonged period. All children showed a favorable recovery of their neurological functions. The total dose normalized to body weight averaged 335 +/- 135 mg/kg, and the mean treatment duration was 93.0 +/- 37.1 h. Data analysis was modeled for each patient to cover all the doses on the whole plasma thiopental concentration-time… CONTINUE READING