Corpus ID: 6833383

Pharmacokinetics of high-dose melphalan in adults: influence of renal function.

  title={Pharmacokinetics of high-dose melphalan in adults: influence of renal function.},
  author={M. Kergueris and N. Milpied and P. Moreau and J. Harousseau and C. Larousse},
  journal={Anticancer research},
  volume={14 6A},
BACKGROUND The pharmacokinetics of melphalan were studied in 20 patients with multiple myeloma, primary amyloidosis or lymphoma after IV dose of 140 mg/m2 infused over 30 minutes (two patients were treated with a higher dose). MATERIALS AND METHODS Six patients received melphalan alone, 8 received melphalan combined with total body irradiation, 2 received busulphan plus melphalan and 4 received the BEAM association (BCNU + etoposide + high dose aracytine + high dose melphalan). Creatinine… Expand

Paper Mentions

Interventional Clinical Trial
High dose chemotherapy with stem cell transplantation is commonplace in the treatment of multiple myeloma. This treatment uses a chemotherapy drug called Melphalan that has been used… Expand
ConditionsAuto Stem Cell Transplant, Multiple Myeloma
Interventional Clinical Trial
In this study the investigators are comparing this standard regimen to the newly established regimen of melphalan and bortezomib.  
ConditionsMultiple Myeloma
Safety of autotransplants with high-dose melphalan in renal failure: a pharmacokinetic and toxicity study.
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Predictors of increased melphalan exposure correlate with overall survival, nonrelapse mortality, and toxicities in patients undergoing reduced-intensity allogeneic stem cell transplantation with fludarabine and melphalan
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  • 2020
Population Pharmacokinetics of Melphalan and Glutathione S‐transferase Polymorphisms in Relation to Side Effects
Pharmacokinetics of high-dose chemotherapy