Pharmacokinetics of hexobarbital in man after intravenous infusion

@article{Breimer1975PharmacokineticsOH,
  title={Pharmacokinetics of hexobarbital in man after intravenous infusion},
  author={D. D. Breimer and C. Honhoff and W. Zilly and E. -I. Richter and Jacques M. van Rossum},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1975},
  volume={3},
  pages={1-11}
}
The plasma levels of hexobarbital in humans were determined during and after a 30-min or 60-min zero-order intravenous infusion. Hexobarbital kinetics could be described by conceiving the body to exhibit two compartments. The plasma concentrations were fitted to the postinfusion equation and the parameters intrinsic to the two- compartment open model were estimated. The elimination half-life varied considerably among the 14 individuals (160–441 min), which could mainly be explained by the… CONTINUE READING

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