Pharmacokinetics of gonadotropin-releasing hormone: comparison of subcutaneous and intravenous routes.

@article{Handelsman1984PharmacokineticsOG,
  title={Pharmacokinetics of gonadotropin-releasing hormone: comparison of subcutaneous and intravenous routes.},
  author={David J Handelsman and Robert P S Jansen and Lee Mallory Boylan and Jennifer A. Spaliviero and John R. Turtle},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1984},
  volume={59 4},
  pages={
          739-46
        }
}
Pulsatile administration of GnRH has been used to stimulate gonadal function in both hypogonadotropic men and women; however, deficient responses were observed with the sc in contrast to the iv route of hormone delivery. To clarify whether this was due to altered bioavailability, we compared the pharmacokinetics of these two routes of GnRH administration by bolus injection and steady state continuous infusion methods. Synthetic GnRH was administered by both sc and iv routes to 14… CONTINUE READING