Pharmacokinetics of glyburide.

  title={Pharmacokinetics of glyburide.},
  author={J. C. G. Pearson},
  journal={The American journal of medicine},
  volume={79 3B},
The pharmacokinetics of glyburide can be described by a two-compartment open model. Terminal-phase descriptions are formulation-dependent and are complicated by apparent food-associated mobilization of drug from the stomach. Some researchers indicate a possible third (or deep) compartment, but this appears to be an artifact of a nonspecific drug assay. Although no accumulation has been observed in short-term studies, further investigation of the possibility of drug accumulation with long-term… CONTINUE READING