Pharmacokinetics of fluvoxamine maleate after increasing single oral doses in healthy subjects.

@article{Vries1993PharmacokineticsOF,
  title={Pharmacokinetics of fluvoxamine maleate after increasing single oral doses in healthy subjects.},
  author={Michiel H De Vries and J. van Harten and P van Bemmel and Maikel Raghoebar},
  journal={Biopharmaceutics & drug disposition},
  year={1993},
  volume={14 4},
  pages={291-6}
}
The pharmacokinetics of fluvoxamine after single oral administration of 25, 50, and 100 mg fluvoxamine maleate was studied in a three-way cross-over study in 12 healthy male subjects. Fluvoxamine was administered orally in a solution. For dose-proportionality, AUC, and Cmax-dose relationships were evaluated by linear regression. Plasma concentrations increased in a linear dose-dependent manner in the dose range between 25 and 100 mg; t1/2 and Tmax showed no significant differences among… CONTINUE READING

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