Pharmacokinetics of fluconazole in the cerebrospinal fluid of children with hydrocephalus.

@article{Bafeltowska2005PharmacokineticsOF,
  title={Pharmacokinetics of fluconazole in the cerebrospinal fluid of children with hydrocephalus.},
  author={Jolanta J Bafeltowska and Ewa Buszman},
  journal={Chemotherapy},
  year={2005},
  volume={51 6},
  pages={370-6}
}
BACKGROUND The aim of this study was to examine the pharmacokinetics of fluconazole in the CSF of children with hydrocephalus during CNS infection treatment after intravenous and/or intraventricular drug administration. Direct fluconazole administration into the ventricular CSF of patients to treat serious CNS infections is an aggressive therapy, and data on the pharmacokinetics of fluconazole in CSF are limited. METHODS A method of fluconazole quantification in CSF by solid-phase extraction… CONTINUE READING