Pharmacokinetics of fluazifop-butyl in human volunteers. II: Dermal dosing.

  title={Pharmacokinetics of fluazifop-butyl in human volunteers. II: Dermal dosing.},
  author={John D Ramsey and Bruce H. Woollen and Timothy R. Auton and P. Batten and J E Leeser},
  journal={Human & experimental toxicology},
  volume={11 4},
1. The absorption of the herbicide fluazifop-butyl (f-b), has been determined from plasma and urine measurements in groups of six male volunteers following dermal administration of 2.5, 25 and 250 micrograms cm-2 from standardized formulations containing 0.05, 0.5 and 5.0% (w/v) fluazifop-butyl to a skin area of 800 cm2. 2. Urinary excretion rate of the principal metabolite fluazifop, following dosing with the 5% formulation, was described by a two-compartment pharmacokinetic model; the average… CONTINUE READING