Pharmacokinetics of florfenicol after intravenous administration in Escherichia coli lipopolysaccharide-induced endotoxaemic sheep.

@article{Perez2015PharmacokineticsOF,
  title={Pharmacokinetics of florfenicol after intravenous administration in Escherichia coli lipopolysaccharide-induced endotoxaemic sheep.},
  author={R. Tamayo Perez and Cristina S D Palma and C Dr{\'a}pela and Marco Sepulveda and Andreas Espinoza and A K Pe{\~n}ailillo},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={2015},
  volume={38 2},
  pages={144-9}
}
Experiments in different animal species have shown that febrile conditions, induced by Escherichia coli lipopolysaccharide (LPS), may alter the pharmacokinetic properties of drugs. The objective was to study the effects of a LPS-induced acute-phase response (APR) model on plasma pharmacokinetics of florfenicol (FFC) after its intravenous administration in sheep. Six adult clinically healthy Suffolk Down sheep, 8 months old and 35.5 ± 2.2 kg in body weight (bw), were distributed through a… CONTINUE READING

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