Pharmacokinetics of famotidine after intravenous administration in liver disease.

  title={Pharmacokinetics of famotidine after intravenous administration in liver disease.},
  author={Kazunori Ohnishi},
  journal={The American journal of gastroenterology},
  volume={86 1},
The pharmacokinetics of famotidine were studied after the administration of a single intravenous dose of 20-mg to seven normal volunteers, six patients with chronic hepatitis, 14 patients with compensated cirrhosis, and seven patients with decompensated cirrhosis. The plasma terminal elimination half-life of famotidine was significantly prolonged and famotidine total body clearance was significantly reduced in patients with decompensated cirrhosis, whose creatinine clearance was 57.2 +/- 6.7 ml… CONTINUE READING


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