Pharmacokinetics of ethanol after oral administration in the fasting state

  title={Pharmacokinetics of ethanol after oral administration in the fasting state},
  author={Paul K. Wilkinson and Allen J. Sedman and Ermelinda Sakmar and Donald R. Kay and John G. Wagner},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
A nonlinear relationship between the total area under the blood ethanol concentration-time curve and the orally administered dose (mg/kg) of ethanol was observed in fasting subjects. A preliminary model, based on physiological considerations, was elaborated and shown, for the first time, to describe the entire time course of blood alcohol concentrations after four different doses of alcohol. The model could be refined by further experimentation. 
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The goal of the present study was to prepare further illustrative examples of a successful use of computational and modeling tools from system engineering in pharmacokinetic investigations, and an advanced modeling method implemented in the computer program named CTDB, and described in the study by Dedik et al[1] was used for modeling purposes.
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Concentrations of ethanol in two segments of the vascular system.
The time courses of capillary and venous blood concentrations of ethanol after oral administration of 0.30 and 0.34 g/kg doses of ethanol to two normal human subjects indicated that, by
Food effects on absorption and metabolism of alcohol.
The concomitant ingestion of various foods with alcohol resulted in a decreased area under the blood alcohol concentration curve, a lower peak concentration and an increased time to reach peak.
Blood ethanol concentrations during and following constant‐rate intravenous infusion of alcohol
The total time course of blood ethanol concentrations in man was defined, both during and postirifusion of ethyl alcohol infusion, with a disproportionate increase in area under the concentration‐time curve with increase in dose.
Ethyl alcohol: Blood levels and performance decrements after oral administration to man
Level of performance on three measures correlated well with dose and blood alcohol levels and decline of effects paralleled the fall in blood levels; the greatest decrement in performance was on the test requiring hand-eye coordination.
Absorption of ethanol from the stomach.
Effects of intravenous and oral propantheline and metoclopramide on ethanol absorption
It is suggested that when propantheline is selected as an anticholinergic for clinical use, there is need for greater awareness of the marked reduction in bioavailability that results when the drug is administered at conventional therapeutic dosage by the oral as opposed to the intravenous route.
Per cent absorbed time plots derived from blood level and/or urinary excretion data.
Here, dA/d t is the rate of absorption or the rate of appearance of the substance in the blood, V is the apparent volume of distribution, C is the blood level in concentration units at time t , dC/dt
Behavioral and Physiological Effects of Alcohol on Man
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Some old equations are reviewed and some new equations have been derived which indicate certain properties of the Michaelis-Menten equation and its integrated forms which indicate the hybrid nature of ko.
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