Pharmacokinetics of ethambutol in children and adults with tuberculosis.

  title={Pharmacokinetics of ethambutol in children and adults with tuberculosis.},
  author={Min Zhu and William J. Burman and Jeffrey R. Starke and Jerry Jean Stambaugh and Phillip Steiner and Amy E Bulpitt and David Ashkin and Barbara Auclair and Shaun E. Berning and Roger W. Jelliffe and George S. Jaresko and Charles A Peloquin},
  journal={The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease},
  volume={8 11},
SETTING Five hospitals in the United States. OBJECTIVE To describe ethambutol pharmacokinetics in children and adults with active tuberculosis (TB). DESIGN Prospective, open-labeled study in 56 adults and 14 children with active tuberculosis who received ethambutol as part of their multidrug TB regimens. RESULTS Most serum samples were collected up to 10 h post dose and assayed using a validated gas chromatography assay with mass selective detection (GC/MS). Concentration data were… CONTINUE READING