Pharmacokinetics of ergotamine in healthy volunteers following oral and rectal dosing

@article{Sanders2004PharmacokineticsOE,
  title={Pharmacokinetics of ergotamine in healthy volunteers following oral and rectal dosing},
  author={Steven W. Sanders and N. Haering and Hans Mosberg and Halvor Jaeger},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={30},
  pages={331-334}
}
SummaryTwenty-four healthy volunteers participated in a study on the disposition of ergotamine following oral and rectal administration. Plasma samples were collected surrounding each dose of medication and a new mass spectrometry method was used for quantitation of the samples. A mean peak plasma concentration of 454 pg/ml was measured an average of 50 min following a 2 mg rectal dose. In contrast, the 2 mg oral dose produced a mean peak plasma concentration of 21 pg/ml an average of 69 min… Expand
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