Pharmacokinetics of enrofloxacin in lactating sheep.

  title={Pharmacokinetics of enrofloxacin in lactating sheep.},
  author={Aneliya Milanova Haritova and Lubomir Dimitrov Lashev and D. A. Pashov},
  journal={Research in veterinary science},
  volume={74 3},
The pharmacokinetics of enrofloxacin (ENR) was investigated after its intravenous (iv) and intramuscular (im) administration in six healthy lactating sheep. After iv ENR injection (as a bolus), the elimination half-life (t(1/2beta)), the volume of distribution (Vd(area)), and the area under the concentration vs. time curve (AUC) were 3.30 (0.36)h, 2.91 (0.17)l/kg and 4.19 (0.18) microg h/ml, respectively. The maximum milk concentrations of ENR (C(max)), the area under the milk concentration vs… CONTINUE READING

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