Pharmacokinetics of drugs in blood. I. Unusual distribution of gentamicin.

@article{Lee1981PharmacokineticsOD,
  title={Pharmacokinetics of drugs in blood. I. Unusual distribution of gentamicin.},
  author={Myung Gull Lee and Li-lin Chen and Susan M Huang and Win L. Chiou},
  journal={Biopharmaceutics & drug disposition},
  year={1981},
  volume={2 1},
  pages={
          89-97
        }
}
Distribution kinetics of gentamicin in whole blood were studied. After spiking human blood to an initial concentration of 20 microgram ml-1, plasma gentamicin concentrations dropped to minima at about 5 min then increased to maxima at about 15 min and remained constant afterwards. A difference of up to 36 per cent between the maximum and minimum was found. The equilibration was faster with lower initial concentrations. These unusual distribution phenomena might be attributed to the Schiff base… CONTINUE READING
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